Nobiletin's usage

Nobiletin is a citrus flavonoids having a structure similar to the tangeretin. He has the typical flavonoid structure and contains 6 methoxyl groups, one more than tangeretin. This high methoxylation increases the hydrophobic character of tangeretin. Pure nobiletin has the appearance of colorless needles, and has a bitter taste. Health Benefits of nobiletin Nobiletin seems to be a very noble phytochemical with many potential health benefits. The most studied properties of nobiletin are its anti-inflammatory and anti-cancer activities. Nobiletin also helps to lower cholesterol and some studies show that it interferes with memory loss to improve and treat acne. Anti-inflammatory Numerous in vivo and in vitro studies, the anti-inflammatory activity of nobiletin and its metabolites have been established. Nobiletin directly acts as an antioxidant, but also interferes with biological inflammatory processes. It inhibits the expression of genes in inflammation involved by blocking the binding of NF-kappaB with DNA. One study showed that nobiletin reduced airway inflammation of asthmatic rats. The treatment of skin cells with nobiletin also reduces inflammation caused by UV-B radiation. Anti-cancer The anti-cancer properties nobiletin are supported by many scientific studies. Nobiletin by its anti-proliferative effect act without toxicity to normal cells. Favourable results were obtained in cancer cell lines of liver, stomach, prostate and colon cancer. Cholesterol-lowering A study using cultured macrophages have shown that lowering cholesterol and atherosclerosis-inhibiting properties of nobiletin. Nobiletin inhibits the formation of macrophage foam cells, macrophages loaded wit lipids, which are based on artery walls. Memory loss A study on a mouse model showed that nobiletin to help improve my memory loss. The brains of the mice were chirurgically be changed in order to obtain models of Alzheimer's disease. It is not known whether nobiletin improved the state of human Alzheimer's patients. Acne Treatment We found in a study showing that nobiletin inhibited sebum production and prevent the proliferation of hamster sebocytes of the cells that form the sebaceous glands. This observation led the researchers to conclude that nobiletin could be used as a drug for the treatment of acne.
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