Fumagillin was originally used against microsporidial parasites Nosema apis
and Nosema ceranae infections in honey bees.Fumagillin is also investigated as an inhibitor of malaria parasite
growth.Fumagillin has been used in
the treatment of microsporidiosis.Fumagillin
is also an amebicide.Fumagillin can
obstruct blood vessel formation by binding to an enzyme called methionine
aminopeptidase 2.As a result, the compound, together with semisynthetic
derivatives,are investigated as a angiogenesis inhibitor in the treatment of
cancer.
Reagent online
About Reagent online the website, please visit http://www.reagent-online.com/.
Tuesday 28 February 2012
Thursday 23 February 2012
the function of Hesperidin
Hesperidin's
function includes antioxidant, anti-inflammatory, hypolipidemic, vasoprotective
and anticarcinogenic and cholesterol lowering . Hesperidin can control following enzymes: phospholipase A2,
lipoxygenase, HMG-CoA reductase and cyclo-oxygenase.
Hesperidin
improves the health of capillaries by decreasing the capillary permeability.Hesperidin is used to reduce hay fever
and other allergic conditions by inhibiting the release of histamine from mast
cells.
Read more: Hesperidin online
Tuesday 21 February 2012
the biochemistry of Tetrodotoxin
The use of this tetrodotoxin as a
biochemical probe has elucidated two distinct types of voltage-gated sodium
channels present in humans: the tetrodotoxin
-sensitive voltage-gated sodium channel (TTX-s Na+ channel) and the tetrodotoxin
-resistant voltage-gated sodium channel (TTX-r Na+ channel). Nerve cells containing TTX-r Na+ channels are located primarily in cardiac tissue, while
nerve cells containing TTX-s Na+
channels dominate the rest of the body. The prevalence of TTX-s Na+ channels in the central nervous system makes tetrodotoxin a valuable agent for the silencing of neural
activity within a cell culture.
The toxin blocks the fast Na+ current in
human myocytes (the contractile cells of the muscles), inhibiting their contraction. By contrast,
the sodium channels in pacemaker cells of the heart are of the slow variety, so
action potentials in the cardiac nodes are not inhibited by the compound. The
myocytes in the atrium, which surround the main cardiac pacemaker, do express
this fast Na+ current and therefore the electrical activity is blocked and the
heart fails to beat.
Blocking of fast Na+ channels has potential
medical use in treating some cardiac arrhythmias. Tetrodotoxin has proved
useful in the treatment of pain from
such diverse problems as terminal cancer, migraines, and heroin withdrawal.
Wednesday 15 February 2012
Polyram is used as fungicide
Fungicides are chemical compounds or
biological organisms used to kill or inhibit fungus or fungal spores. Fungi can
cause serious damage in agriculture, leading to critical yield, quality and
profit. Fungicides are both in agriculture and for the treatment of fungal
infections in animals used to fight. Chemicals are used to Oomycetes, fungi do
not control it, even as fungicides called Oomycetes use the same mechanisms as
fungi infect plants.
Polyram is a yellow power.Non corrosive.Insoluble in water.Polyram is used as fungicide.Thin and form dithiocarbamates decompose slowly in aqueous solution of carbon disulfide and methyl amine or other amines.Such decompositions are accelerated by acids and bases.Insoluble in water.
Read more:Polyram online
Polyram is a yellow power.Non corrosive.Insoluble in water.Polyram is used as fungicide.Thin and form dithiocarbamates decompose slowly in aqueous solution of carbon disulfide and methyl amine or other amines.Such decompositions are accelerated by acids and bases.Insoluble in water.
Read more:Polyram online
Tuesday 14 February 2012
Nobiletin's usage
Nobiletin is a citrus flavonoids having a structure similar to the tangeretin. He has the typical flavonoid structure and contains 6 methoxyl groups, one more than tangeretin. This high methoxylation increases the hydrophobic character of tangeretin. Pure nobiletin has the appearance of colorless needles, and has a bitter taste.
Health Benefits of nobiletin
Nobiletin seems to be a very noble phytochemical with many potential health benefits. The most studied properties of nobiletin are its anti-inflammatory and anti-cancer activities. Nobiletin also helps to lower cholesterol and some studies show that it interferes with memory loss to improve and treat acne.
Anti-inflammatory
Numerous in vivo and in vitro studies, the anti-inflammatory activity of nobiletin and its metabolites have been established. Nobiletin directly acts as an antioxidant, but also interferes with biological inflammatory processes. It inhibits the expression of genes in inflammation involved by blocking the binding of NF-kappaB with DNA. One study showed that nobiletin reduced airway inflammation of asthmatic rats. The treatment of skin cells with nobiletin also reduces inflammation caused by UV-B radiation.
Anti-cancer
The anti-cancer properties nobiletin are supported by many scientific studies. Nobiletin by its anti-proliferative effect act without toxicity to normal cells. Favourable results were obtained in cancer cell lines of liver, stomach, prostate and colon cancer.
Cholesterol-lowering
A study using cultured macrophages have shown that lowering cholesterol and atherosclerosis-inhibiting properties of nobiletin. Nobiletin inhibits the formation of macrophage foam cells, macrophages loaded wit lipids, which are based on artery walls.
Memory loss
A study on a mouse model showed that nobiletin to help improve my memory loss. The brains of the mice were chirurgically be changed in order to obtain models of Alzheimer's disease. It is not known whether nobiletin improved the state of human Alzheimer's patients.
Acne Treatment
We found in a study showing that nobiletin inhibited sebum production and prevent the proliferation of hamster sebocytes of the cells that form the sebaceous glands. This observation led the researchers to conclude that nobiletin could be used as a drug for the treatment of acne.
Read more>>nobiletin online
Read more>>nobiletin online
Monday 13 February 2012
The effect of Podophyllin
The American Social Health Association
reports that at any time, 20 million people in the United States suffer from an
outbreak of human papillomavirus. Also known as genital warts or HPV, human
papillomavirus is a sexually transmitted disease that sometimes leads to the formation
of tumors in the reproductive organs of men and women. Although there is no
cure for HPV, there are medications available to treat your outbreaks of
genital warts, including the prescription cream Podocon-25 or podophyllin. Despite
its effectiveness podophyllin is not for everyone, since it presents several
risks for side effects and complications in some patients.
Even without excessive amounts of the active substance in the blood, podophyllin has the potential result, a number of medical complications. Polyneuritis or widespread inflammation of the nerves is possible, what effects on the cardiovascular and respiratory system in addition to numbness in the limbs. Podophyllin sometimes causes a lack of white blood cells or platelets in your body that increases the risk of developing serious infections or bleeding in the brain. In very rare cases, causes of drug use, coma or even death.
Read more>>Podophyllin online
Even without excessive amounts of the active substance in the blood, podophyllin has the potential result, a number of medical complications. Polyneuritis or widespread inflammation of the nerves is possible, what effects on the cardiovascular and respiratory system in addition to numbness in the limbs. Podophyllin sometimes causes a lack of white blood cells or platelets in your body that increases the risk of developing serious infections or bleeding in the brain. In very rare cases, causes of drug use, coma or even death.
Read more>>Podophyllin online
Tuesday 7 February 2012
Boc-Glu(OBzl)-Pam Resin is your need
Product name: Boc-Glu(OBzl)-Pam Resin
Molecular Formula: C17H22NO5R
Molecular Weight: 320.36g/mol
Description:
Boc-Glu(OBzl)-Pam Resin is 0.3-0.8mmol/g.The particle is 100-200 mesh.It is 1% DVB cross-linked.This product should be sealed from 2-8°C.
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