the descrition of Fumagillin

Fumagillin was originally used against microsporidial parasites Nosema apis and Nosema ceranae infections in honey bees.Fumagillin is also investigated as an inhibitor of malaria parasite growth.Fumagillin has been used in the treatment of microsporidiosis.Fumagillin is also an amebicide.Fumagillin can obstruct blood vessel formation by binding to an enzyme called methionine aminopeptidase 2.As a result, the compound, together with semisynthetic derivatives,are investigated as a angiogenesis inhibitor in the treatment of cancer.

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the function of Hesperidin

Hesperidin's function includes antioxidant, anti-inflammatory, hypolipidemic, vasoprotective and anticarcinogenic and cholesterol lowering . Hesperidin can control following enzymes: phospholipase A2, lipoxygenase, HMG-CoA reductase and cyclo-oxygenase.

Hesperidin improves the health of capillaries by decreasing the capillary permeability.Hesperidin is used to reduce hay fever and other allergic conditions by inhibiting the release of histamine from mast cells.

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the biochemistry of Tetrodotoxin

The use of this tetrodotoxin  as a biochemical probe has elucidated two distinct types of voltage-gated sodium channels present in humans: the tetrodotoxin -sensitive voltage-gated sodium channel (TTX-s Na+ channel) and the tetrodotoxin -resistant voltage-gated sodium channel (TTX-r Na+ channel). Nerve cells containing TTX-r Na+ channels are located primarily in cardiac tissue, while nerve cells containing TTX-s Na+ channels dominate the rest of the body. The prevalence of TTX-s Na+ channels in the central nervous system makes tetrodotoxin  a valuable agent for the silencing of neural activity within a cell culture.

The toxin blocks the fast Na+ current in human myocytes (the contractile cells of the muscles),  inhibiting their contraction. By contrast, the sodium channels in pacemaker cells of the heart are of the slow variety, so action potentials in the cardiac nodes are not inhibited by the compound. The myocytes in the atrium, which surround the main cardiac pacemaker, do express this fast Na+ current and therefore the electrical activity is blocked and the heart fails to beat.

Blocking of fast Na+ channels has potential medical use in treating some cardiac arrhythmias. Tetrodotoxin  has proved useful in the treatment of pain  from such diverse problems as terminal cancer, migraines, and heroin withdrawal.

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Polyram is used as fungicide

Fungicides are chemical compounds or biological organisms used to kill or inhibit fungus or fungal spores. Fungi can cause serious damage in agriculture, leading to critical yield, quality and profit. Fungicides are both in agriculture and for the treatment of fungal infections in animals used to fight. Chemicals are used to Oomycetes, fungi do not control it, even as fungicides called Oomycetes use the same mechanisms as fungi infect plants.
Polyram is a yellow power.Non corrosive.Insoluble in water.Polyram is used as fungicide.Thin and form dithiocarbamates decompose slowly in aqueous solution of carbon disulfide and methyl amine or other amines.Such decompositions are accelerated by acids and bases.Insoluble in water.
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Nobiletin's usage

Nobiletin is a citrus flavonoids having a structure similar to the tangeretin. He has the typical flavonoid structure and contains 6 methoxyl groups, one more than tangeretin. This high methoxylation increases the hydrophobic character of tangeretin. Pure nobiletin has the appearance of colorless needles, and has a bitter taste. Health Benefits of nobiletin Nobiletin seems to be a very noble phytochemical with many potential health benefits. The most studied properties of nobiletin are its anti-inflammatory and anti-cancer activities. Nobiletin also helps to lower cholesterol and some studies show that it interferes with memory loss to improve and treat acne. Anti-inflammatory Numerous in vivo and in vitro studies, the anti-inflammatory activity of nobiletin and its metabolites have been established. Nobiletin directly acts as an antioxidant, but also interferes with biological inflammatory processes. It inhibits the expression of genes in inflammation involved by blocking the binding of NF-kappaB with DNA. One study showed that nobiletin reduced airway inflammation of asthmatic rats. The treatment of skin cells with nobiletin also reduces inflammation caused by UV-B radiation. Anti-cancer The anti-cancer properties nobiletin are supported by many scientific studies. Nobiletin by its anti-proliferative effect act without toxicity to normal cells. Favourable results were obtained in cancer cell lines of liver, stomach, prostate and colon cancer. Cholesterol-lowering A study using cultured macrophages have shown that lowering cholesterol and atherosclerosis-inhibiting properties of nobiletin. Nobiletin inhibits the formation of macrophage foam cells, macrophages loaded wit lipids, which are based on artery walls. Memory loss A study on a mouse model showed that nobiletin to help improve my memory loss. The brains of the mice were chirurgically be changed in order to obtain models of Alzheimer's disease. It is not known whether nobiletin improved the state of human Alzheimer's patients. Acne Treatment We found in a study showing that nobiletin inhibited sebum production and prevent the proliferation of hamster sebocytes of the cells that form the sebaceous glands. This observation led the researchers to conclude that nobiletin could be used as a drug for the treatment of acne.
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The effect of Podophyllin

The American Social Health Association reports that at any time, 20 million people in the United States suffer from an outbreak of human papillomavirus. Also known as genital warts or HPV, human papillomavirus is a sexually transmitted disease that sometimes leads to the formation of tumors in the reproductive organs of men and women. Although there is no cure for HPV, there are medications available to treat your outbreaks of genital warts, including the prescription cream Podocon-25 or podophyllin. Despite its effectiveness podophyllin is not for everyone, since it presents several risks for side effects and complications in some patients.

Even without excessive amounts of the active substance in the blood, podophyllin has the potential result, a number of medical complications. Polyneuritis or widespread inflammation of the nerves is possible, what effects on the cardiovascular and respiratory system in addition to numbness in the limbs. Podophyllin sometimes causes a lack of white blood cells or platelets in your body that increases the risk of developing serious infections or bleeding in the brain. In very rare cases, causes of drug use, coma or even death.
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Boc-Glu(OBzl)-Pam Resin is your need

Product name: Boc-Glu(OBzl)-Pam Resin

Molecular Formula: C17H22NO5R

Molecular Weight: 320.36g/mol

Description:

Boc-Glu(OBzl)-Pam Resin is 0.3-0.8mmol/g.The particle is 100-200 mesh.It is 1% DVB cross-linked.This product should be sealed from 2-8°C.

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Boc-Tyr(2-BrZ)-Merrifield Resin is your want

Boc-Tyr(2-BrZ)-Merrifield Resin is biologically active substances related  in a variety of cellular functions of a living body, and its molecular structure between amino acids and proteins, according to a certain order by a variety of amino acids by a combination of peptide bond compounds.

Boc-Tyr(2-BrZ)-Merrifield Resin；Boc-Tyr(2-BrZ)-Merrifield Resin

Boc-Tyr(2-BrZ)-Merrifield Resin is 0.3-0.8mmol/g.The particle is 100-200 mesh.It is 1% DVB cross-linked.This product should be sealed from 2-8°C.

Molecular Formula: C22H23BrNO6R

Molecular Weight: 477.33g/mol

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What is Melibiose

Melibiose is Disaccharide formed by glucose and galactose.

Melibiose is a disaccharide formed by an alpha linkage between galactose and glucose (D-Gal-α(1→6)-D-Glc). It can be formed by invertase mediated hydrolysis of raffinose, which produces melibiose and fructose.

Melibiose can be broken down into its component saccharides, glucose and galactose, by the enzyme encoded by the gene GLA.

CAS: 585-99-9

Molecular Formula: C12H22O11

Molecular Weight: 342.30g/mol

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How to know about Panaxadiol

Panaxadiol is useful to the human nervous system, endocrine and circulatory system to regulate the role, as a tonic medicine, it can be used in a cream, lotion and other skin care cosmetics as a nutritional additive.

Panaxadiol contains a variety of nutrients, can increase cell viability, and promote the metabolism and peripheral vascular Chen circulation effect. For skin care products, make the skin smooth, soft and flexible, reducing wrinkles, aging, can inhibit melanin production. Used in hair care products, can improve hair strength, to prevent hair loss and hair regeneration performance, long-term use to make the hair black and shiny. Ginseng is commonly used in the leaching solution. Ginseng extract is widely used in cosmetics, the preparation of cream (cream, acne cream, wrinkle cream, etc.), lotions and hair care products.

Panaxadiol can enhance the anti-cancer effects of 5-FU on human colorectal cancer cells through the regulation of cell cycle transition and the induction of apoptotic cells.

CAS: 19666-76-3

Molecular Formula: C30H52O3

Molecular Weight: 460.73g/mol

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