Beta-NGF regulates the growth, development, survival and repair of the vertebrate nervous system. Specifically, it is involved in the survival, differentiation and functional activities of sensory and sympathetic neurons in the peripheral nervous system.
Beta-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.
Beta-NGF is a potent neurotrophic factor that signals through its receptor beta-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. beta-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival.
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